# CIRCULATING TUMOR DNA BASED DECISION FOR ADJUVANT TREATMENT IN COLON CANCER STAGE II

Source: https://onco.cc/trials/nct04120701/  
OnCo record `nct04120701` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of fOLFOX (5-FU, leucovorin, oxaliplatin) in colorectal cancer, run by Centre Hospitalier Universitaire Dijon, now recruiting.

## Summary

CIRCULATING TUMOR DNA BASED DECISION FOR ADJUVANT TREATMENT IN COLON CANCER STAGE II is a phase 3, randomised interventional study registered as NCT04120701 by Centre Hospitalier Universitaire Dijon, with a registry enrolment figure of 1980 participants, started 2020-01-17 and due to reach its primary completion in 2032-03. Interventions recorded: mFOLFOX6. Conditions listed: Patients With Resected Stage II Colon Cancer. Primary outcome: 3-year Disease-Free Survival in ctDNA positive patients. Colorectal eligibility wording from the registry: "* Histologically confirmed stage II colon and high rectum adenocarcinoma excluding low and medium rectal cancers (tumor location ≥ 12 cm from the anal verge by endoscopy and/or above the peritoneal reflection at surgery are still eligible), without gross or microscopic evidence of residual disease a". Sites: France. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: CIRCULATE
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT04120701
- Phase: 3
- Setting: CIRCULATING TUMOR DNA BASED DECISION FOR ADJUVANT TREATMENT IN COLON CANCER STAGE II
- Sponsor: Centre Hospitalier Universitaire Dijon
- Enrolled: 1980

## Sources

- ClinicalTrials.gov NCT04120701: https://clinicaltrials.gov/study/NCT04120701

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [MRD / molecular residual disease testing](https://onco.cc/technologies/mrd-testing/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [FOLFOX (5-FU, leucovorin, oxaliplatin)](https://onco.cc/drugs/folfox/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

---
JSON: https://onco.cc/api/v1/entities/nct04120701.json