# S1827 (MAVERICK) Testing Whether the Use of Brain Scans Alone Instead of Brain Scans Plus Preventive Brain Radiation Affects Lifespan in Patients With Small Cel

Source: https://onco.cc/trials/nct04155034/  
OnCo record `nct04155034` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in lung cancer, run by SWOG Cancer Research Network, active but no longer recruiting.

## Summary

S1827 (MAVERICK) Testing Whether the Use of Brain Scans Alone Instead of Brain Scans Plus Preventive Brain Radiation Affects Lifespan in Patients With Small Cell Lung Cancer is a phase 3, randomised interventional study registered as NCT04155034 by SWOG Cancer Research Network, with a registry enrolment figure of 668 participants, started 2020-05-04 and due to reach its primary completion in 2026-03-17. Interventions recorded: Magnetic Resonance Imaging; Prophylactic Cranial Irradiation. Conditions listed: Extensive Stage Lung Small Cell Carcinoma; Limited Stage Lung Small Cell Carcinoma; Lung Small Cell Carcinoma. Primary outcome: Overall survival (OS). Lung eligibility wording from the registry: "* Patient must have a histologically confirmed diagnosis of small-cell lung cancer (SCLC)". Sites: Canada, Chile, Colombia, Mexico, Saudi Arabia, South Korea, United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-25
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT04155034
- Phase: 3
- Setting: MRI Brain Surveillance Alone Versus MRI Surveillance and Prophylactic Cranial Irradiation (PCI): A Randomized Phase III Trial in Small-Cell Lung Cancer (MAVERICK)
- Sponsor: SWOG Cancer Research Network
- Enrolled: 668

## Sources

- ClinicalTrials.gov NCT04155034: https://clinicaltrials.gov/study/NCT04155034

## Connected records

- cancers: [Extensive-stage small-cell lung cancer](https://onco.cc/cancers/extensive-stage-sclc/), [Limited-stage small-cell lung cancer](https://onco.cc/cancers/limited-stage-sclc/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- companies: [SWOG Cancer Research Network](https://onco.cc/companies/swog/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct04155034.json