# Testing the Addition of a New Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiotherapy in Patients With Locally Advanced Pancreatic Cancer

Source: https://onco.cc/trials/nct04172532/  
OnCo record `nct04172532` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial in pancreatic cancer, run by National Cancer Institute (NCI), now recruiting.

## Summary

Testing the Addition of a New Anti-cancer Drug, M3814 (Peposertib), to the Usual Radiotherapy in Patients With Locally Advanced Pancreatic Cancer is a phase 1/2, randomised interventional study registered as NCT04172532 by National Cancer Institute (NCI), with a registry enrolment figure of 92 participants, started 2021-01-11 and due to reach its primary completion in 2027-08-01. Interventions recorded: Biopsy Procedure; Biospecimen Collection; Computed Tomography; Hypofractionated Radiation Therapy; Magnetic Resonance Imaging; Peposertib; Placebo Administration. Conditions listed: Locally Advanced Pancreatic Adenocarcinoma; Stage III Pancreatic Cancer AJCC v8. Primary outcome: Maximum tolerated dose (Phase I); Recommended phase 2 dose (Phase I); Progression-free survival rate (Phase II). Pancreatic eligibility wording from the registry: "* Patients must have pathologically confirmed pancreatic adenocarcinoma". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; pancreatic-deep-dive
- Registry id: NCT04172532
- Phase: 1/2
- Setting: A Phase 1/2 Study of M3814 (Peposertib) in Combination With Hypofractionated Radiotherapy for the Treatment of Locally Advanced Pancreatic Adenocarcinoma
- Sponsor: National Cancer Institute (NCI)
- Enrolled: 92

## Sources

- ClinicalTrials.gov NCT04172532: https://clinicaltrials.gov/study/NCT04172532

## Connected records

- cancers: [Locally advanced unresectable pancreatic ductal adenocarcinoma](https://onco.cc/cancers/locally-advanced-pdac/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Pancreatic cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/pancreatic-trials-open-today/)

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