# A Randomized Phase III Study Comparing Maintenance Treatment With Fluoropyrimidine + Bevacizumab Versus Fluoropyrimidine After Induction Chemotherapy for a Meta

Source: https://onco.cc/trials/nct04188145/  
OnCo record `nct04188145` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of bevacizumab (glioblastoma use) in colorectal cancer, run by Centre Hospitalier Universitaire Dijon, active but no longer recruiting.

## Summary

A Randomized Phase III Study Comparing Maintenance Treatment With Fluoropyrimidine + Bevacizumab Versus Fluoropyrimidine After Induction Chemotherapy for a Metastatic Colorectal Cancer is a phase 3, randomised interventional study registered as NCT04188145 by Centre Hospitalier Universitaire Dijon, with a registry enrolment figure of 400 participants, started 2020-01-27 and due to reach its primary completion in 2029-09. Interventions recorded: Fluoropyrimidine; Bevacizumab. Conditions listed: Metastatic Colorectal Cancer. Primary outcome: The Time-to-Treatment Failure (TTF). Colorectal eligibility wording from the registry: "* Histologically confirmed metastatic colorectal adenocarcinoma before induction treatment". Sites: France. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-24
- Also known as: BEVAMAINT
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT04188145
- Phase: 3
- Setting: A Randomized Phase III Study Comparing Maintenance Treatment With Fluoropyrimidine + Bevacizumab Versus Fluoropyrimidine After Induction Chemotherapy for a Metastatic Colorectal Cancer
- Sponsor: Centre Hospitalier Universitaire Dijon
- Enrolled: 400

## Sources

- ClinicalTrials.gov NCT04188145: https://clinicaltrials.gov/study/NCT04188145

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- drugs: [Bevacizumab (glioblastoma use)](https://onco.cc/drugs/bevacizumab-glioma/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct04188145.json