# Neoadjuvant mFOLFOXIRI Plus Bevacizumab in Patients With High-Risk Locally Advanced Rectal Cancer

Source: https://onco.cc/trials/nct04215731/  
OnCo record `nct04215731` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in colorectal cancer, run by Yanhong Deng, now recruiting.

## Summary

Neoadjuvant mFOLFOXIRI Plus Bevacizumab in Patients With High-Risk Locally Advanced Rectal Cancer is a phase 3, randomised interventional study registered as NCT04215731 by Yanhong Deng, with a registry enrolment figure of 582 participants, started 2020-03-27 and due to reach its primary completion in 2026-09-01. Interventions recorded: Neoadjuvant chemotherapy with mFOLFOXIRI plus bevacizumab; Restaging; Concomitant Chemoradiotherapy; Surgery; Chemoradiotherapy (only when patients with MRF involved or ycT4a/b by restaging); Induction chemotherpay with FOLFOX. Conditions listed: Rectal Cancer. Primary outcome: Disease-free survival. Colorectal eligibility wording from the registry: "Histological or cytological documentation of adenocarcinoma of the rectal (\<12 cm from the anal verge)". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: FOBEAR
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT04215731
- Phase: 3
- Setting: Neoadjuvant mFOLFOXIRI Plus Bevacizumab Versus Induction FOLFOX Followed by Concomitant Chemoradiotherapy in Patients With High-Risk Locally Advanced Rectal Cancer: Multicenter Randomized Phase III Trial
- Sponsor: Yanhong Deng
- Enrolled: 582

## Sources

- ClinicalTrials.gov NCT04215731: https://clinicaltrials.gov/study/NCT04215731

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct04215731.json