# Short RT Versus RCT,Followed by Chemo and Organ Preservation for Interm and High-risk Rectal Cancer Patients

Source: https://onco.cc/trials/nct04246684/  
OnCo record `nct04246684` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of fluorouracil (5-FU) in colorectal cancer, run by Prof. Dr. med. Claus Rödel, active but no longer recruiting.

## Summary

Short RT Versus RCT,Followed by Chemo and Organ Preservation for Interm and High-risk Rectal Cancer Patients is a phase 3, randomised interventional study registered as NCT04246684 by Prof. Dr. med. Claus Rödel, with a registry enrolment figure of 702 participants, started 2020-11-05 and due to reach its primary completion in 2026-09-15. Interventions recorded: Oxaliplatin, 85 mg/m2; 5FU; 2400 mg/m2; 5FU, 250 mg/m2; 5FU, 2400 mg/m2; Oxaliplatin 50 mg/m2; Folinic Acid, 400 mg/m2; Radiotherapy control, 5x5 Gy: 25 Gy; Capecitabine, 1000 mg/m2; Oxaliplatin 85 mg/m2; radiotherapy experimental, 30 x 1,8 Gy: 54 Gy; Capecitabine, 825 mg/m2; Oxaliplatin, 130 mg/m2. Conditions listed: Rectal Cancer Stage III. Primary outcome: organ preservation. Colorectal eligibility wording from the registry: "* diagnosis of rectal adenocarcinoma localised 0 - 12 cm from the anocutaneous line as measured by rigid rectoscopy (i". Sites: Germany. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT04246684
- Phase: 3
- Setting: Short-course Radiotherapy Versus Chemoradiotherapy, Followed by Consolidation Chemotherapy, and Selective Organ Preservation for MRI-defined Intermediate and High-risk Rectal Cancer Patients
- Sponsor: Prof. Dr. med. Claus Rödel
- Enrolled: 702

## Sources

- ClinicalTrials.gov NCT04246684: https://clinicaltrials.gov/study/NCT04246684

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- drugs: [Fluorouracil (5-FU)](https://onco.cc/drugs/fluorouracil/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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