# CompassHER2-pCR

Source: https://onco.cc/trials/nct04266249/  
OnCo record `nct04266249` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CompassHER2-pCR tests whether people whose cancer clears with a shorter course of pre-surgery treatment can receive less chemotherapy afterward. Further treatment depends on what is found at surgery.

## Summary

CompassHER2-pCR tests whether people whose cancer clears with a shorter course of pre-surgery treatment can receive less chemotherapy afterward. Further treatment depends on what is found at surgery.

Interventional study registered as NCT04266249, sponsored by ECOG-ACRIN Cancer Research Group. Registry phase: 2. Registry enrollment is 2,175 participants (actual). Registry status checked October 10, 2026: active not recruiting. UCSF lists this study as closed to local enrollment; local availability and overall registry status are separate. See the registry for full eligibility and current sites.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-10-10
- Also known as: CompassHER2-pCR: Decreasing Chemotherapy for Breast Cancer Patients After Pre-surgery Chemo and Targeted Therapy
- Tags: ucsf-breast-coverage; interventional
- Registry id: NCT04266249
- Phase: 2
- Setting: Early HER2-positive breast cancer treated before surgery
- Sponsor: ECOG-ACRIN Cancer Research Group
- Enrolled: 2175

## Sources

- ClinicalTrials.gov NCT04266249: https://clinicaltrials.gov/study/NCT04266249
- UCSF study listing and local availability: https://clinicaltrials.ucsf.edu/trial/NCT04266249

## Connected records

- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/)
- drugs: [Docetaxel](https://onco.cc/drugs/docetaxel/), [Nab-paclitaxel](https://onco.cc/drugs/nab-paclitaxel/), [Paclitaxel / nab-paclitaxel](https://onco.cc/drugs/paclitaxel/), [Pertuzumab](https://onco.cc/drugs/pertuzumab/), [Trastuzumab](https://onco.cc/drugs/trastuzumab/), [Trastuzumab emtansine](https://onco.cc/drugs/trastuzumab-emtansine/)
- institutions: [UCSF Helen Diller Family Comprehensive Cancer Center](https://onco.cc/institutions/ucsf/)

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