# Surgery Plus Chemo Versus Chemoradiotherapy Followed by Surgery Plus Chemo for Locally Recurrent Rectal Cancer

Source: https://onco.cc/trials/nct04288999/  
OnCo record `nct04288999` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in colorectal cancer, run by National Cancer Center Hospital East, now recruiting.

## Summary

Surgery Plus Chemo Versus Chemoradiotherapy Followed by Surgery Plus Chemo for Locally Recurrent Rectal Cancer is a phase 3, randomised interventional study registered as NCT04288999 by National Cancer Center Hospital East, with a registry enrolment figure of 110 participants, started 2019-10-01 and due to reach its primary completion in 2025-08. Interventions recorded: Chemotherapy; Preoperative radiotherapy; Procedure. Conditions listed: Rectal Cancer Recurrent. Primary outcome: Locally recurrent free survival. Colorectal eligibility wording from the registry: "Histopathologically proven adenocarcinoma or adenosquamous carcinoma on the resected specimen of the initial rectal cancer or endoscopic biopsy from the initial rectal cancer". Sites: Japan. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: JCOG1801
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT04288999
- Phase: 3
- Setting: JCOG1801: A Phase III Randomized Controlled Trial Comparing Surgery Plus Adjuvant Chemotherapy With Preoperative Chemoradiotherapy Followed by Surgery Plus Adjuvant Chemotherapy for Locally Recurrent Rectal Cancer (RC-SURVIVE Study)
- Sponsor: National Cancer Center Hospital East
- Enrolled: 110

## Sources

- ClinicalTrials.gov NCT04288999: https://clinicaltrials.gov/study/NCT04288999

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct04288999.json