# Carboplatin Intensified Chemotherapy for TRIple NEgative Breast Cancer(CITRINE)

Source: https://onco.cc/trials/nct04296175/  
OnCo record `nct04296175` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of epirubicin, paclitaxel / nab-paclitaxel and carboplatin in triple-negative breast cancer, run by Fudan University, active but no longer recruiting.

## Summary

Carboplatin Intensified Chemotherapy for TRIple NEgative Breast Cancer(CITRINE) is a phase 3, randomised interventional study registered as NCT04296175 by Fudan University, with a registry enrolment figure of 808 participants, started 2020-03-05 and due to reach its primary completion in 2025-03-10. Interventions recorded: Epirubicin; CTX; Paclitaxel; ddEpirubicin; ddCTX; Paclitaxel(with carbo); Carboplatin. Conditions listed: Triple-negative Breast Cancer. Triple-negative eligibility wording from the registry: "Histologically documented TNBC after early breast cancer surgery (absence of HER2, ER, and PR expression)". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-24
- Also known as: CITRINE
- Tags: ctgov-ingest; tnbc-deep-dive
- Registry id: NCT04296175
- Phase: 3
- Setting: A Prospective, Single Center, Randomized, Open-labled Stage III Clinical Trial Comparing the Efficacy and Safety of Anthracyclin Followed by Weekly Paclitaxel Versus Dose-dense Anthracyclin Followed by Weekly Paclitaxel Versus Dose-dense Anthracyclin Followed by Weekly Paclitaxel Combined With Carboplatin for High-risk, Triple-negative Early Breast Cancer
- Sponsor: Fudan University
- Enrolled: 808

## Sources

- ClinicalTrials.gov NCT04296175: https://clinicaltrials.gov/study/NCT04296175

## Connected records

- cancers: [Early triple-negative breast cancer](https://onco.cc/cancers/tnbc-early/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [Carboplatin](https://onco.cc/drugs/carboplatin/), [Epirubicin](https://onco.cc/drugs/epirubicin/), [Paclitaxel / nab-paclitaxel](https://onco.cc/drugs/paclitaxel/)
- terms: [Triple-negative breast cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/tnbc-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct04296175.json