# Natural Killer Cell (CYNK-001) Infusions in Adults with AML

Source: https://onco.cc/trials/nct04310592/  
OnCo record `nct04310592` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1 trial of CYNK-001 run by Celularity Incorporated, terminated.

## Summary

Natural Killer Cell (CYNK-001) Infusions in Adults with AML is a phase 1 interventional study registered as NCT04310592 by Celularity Incorporated, with 27 participants enrolled, started 2020-03-12. Conditions recorded: Leukemia, Leukemia, Myeloid, Leukemia, Myeloid, Acute, Neoplasms by Histologic Type, Neoplasms, Immunosuppressive Agents, Immunologic Factors, Physiological Effects of Drugs, Alkylating Agents, Antimetabolites, Antineoplastic, Antiviral Agents, Analgesics, Non-narcotic, Anti-infective Agents, Analgesics, Peripheral Nervous System Agents, Hematologic Diseases, Hematologic Neoplasms, Leukemia in Remission, Relapsed Adult AML and Refractory AML. Interventions recorded: CYNK-001.

## Fields

- Kind: Trial
- Status: historic
- Last checked: 2026-11-03
- Tags: pipeline; ctgov-ingest
- Registry id: NCT04310592
- Phase: 1
- Setting: A Phase I Multi-dose Study of Human Placental Hematopoietic Stem Cell Derived Natural Killer Cells (CYNK-001) with or Without Recombinant Human Interleukin-2 (rhIL-2) in Adults with Primary or Secondary Acute Myeloid Leukemia (AML) in Morphologic Complete Remission with Minimal Residual Disease (MRD) or Relapsed/refractory (R/R) AML
- Sponsor: Celularity Incorporated
- Enrolled: 27

## Sources

- ClinicalTrials.gov NCT04310592: https://clinicaltrials.gov/study/NCT04310592

## Connected records

- cancers: [Acute myeloid leukaemia](https://onco.cc/cancers/aml/), [Leukaemia (all types)](https://onco.cc/cancers/leukaemia/), [Metastatic cancer (cancer that has spread)](https://onco.cc/cancers/metastatic-cancer/)
- drugs: [CYNK-001](https://onco.cc/drugs/cynk-001/)
- companies: [Celularity](https://onco.cc/companies/celularity/)

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