# Cryoablation in Combination (or Not) With Pembrolizumab and Pemetrexed-carboplatin in 1st-line Treatment for Patients With Metastatic Lung Adenocarcinoma

Source: https://onco.cc/trials/nct04339218/  
OnCo record `nct04339218` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of pembrolizumab, pemetrexed and carboplatin in lung cancer, run by Institut Bergonié, now recruiting.

## Summary

Cryoablation in Combination (or Not) With Pembrolizumab and Pemetrexed-carboplatin in 1st-line Treatment for Patients With Metastatic Lung Adenocarcinoma is a phase 3, randomised interventional study registered as NCT04339218 by Institut Bergonié, with a registry enrolment figure of 214 participants, started 2020-08-28 and due to reach its primary completion in 2026-08-27. Interventions recorded: Cryoablation; Pembrolizumab; Pemetrexed; Carboplatin. Conditions listed: Lung Adenocarcinoma; Cryotherapy Effect. Primary outcome: 1-year overall survival rate. Lung eligibility wording from the registry: "Histologically or cytologically confirmed non-small lung adenocarcinoma". Sites: France. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-25
- Also known as: CRYOMUNE
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT04339218
- Phase: 3
- Setting: Cryoablation in Combination (or Not) With Pembrolizumab and Pemetrexed-carboplatin in First-line Treatment for Patients With Metastatic Lung Adenocarcinoma: A Randomized Phase III Study
- Sponsor: Institut Bergonié
- Enrolled: 214

## Sources

- ClinicalTrials.gov NCT04339218: https://clinicaltrials.gov/study/NCT04339218

## Connected records

- cancers: [Lung cancer (all types)](https://onco.cc/cancers/lung-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/), [Platinum agents](https://onco.cc/technologies/platinum/), [Thermal ablation (RFA, microwave, cryo)](https://onco.cc/technologies/thermal-ablation/)
- drugs: [Carboplatin](https://onco.cc/drugs/carboplatin/), [Pembrolizumab](https://onco.cc/drugs/pembrolizumab/), [Pemetrexed](https://onco.cc/drugs/pemetrexed/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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