# Induction Chemotherapy for Locally Recurrent Rectal Cancer

Source: https://onco.cc/trials/nct04389086/  
OnCo record `nct04389086` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in colorectal cancer, run by Catharina Ziekenhuis Eindhoven, now recruiting.

## Summary

Induction Chemotherapy for Locally Recurrent Rectal Cancer is a phase 3, randomised interventional study registered as NCT04389086 by Catharina Ziekenhuis Eindhoven, with a registry enrolment figure of 364 participants, started 2020-11-13 and due to reach its primary completion in 2024-03-01. Interventions recorded: Combination drug; Chemoradiotherapy; Surgery locally recurrent rectal cancer. Conditions listed: Recurrent Rectal Cancer. Primary outcome: Proportion of patients with a clear resection margin. Colorectal eligibility wording from the registry: "* Confirmed locally recurrent rectal cancer after total or partial mesorectal resection for rectal or distal sigmoidal cancer either by histopathology ór clinically proven (evidence on imaging in combination with clinical findings, with consensus in MDT)". Sites: Belgium, Netherlands, Norway, Portugal, Sweden. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: PelvEx II
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT04389086
- Phase: 3
- Setting: Multicentre, Open-label, Randomised, Controlled, Parallel Arms Clinical Trial of Induction Chemotherapy Followed by Chemoradiotherapy Versus Chemoradiotherapy Alone as Neoadjuvant Treatment for Locally Recurrent Rectal Cancer - PelvEx II
- Sponsor: Catharina Ziekenhuis Eindhoven
- Enrolled: 364

## Sources

- ClinicalTrials.gov NCT04389086: https://clinicaltrials.gov/study/NCT04389086

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct04389086.json