# BOLD-100 in Combination With FOLFOX for the Treatment of Advanced Solid Tumours

Source: https://onco.cc/trials/nct04421820/  
OnCo record `nct04421820` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of Leucovorin, FLOT, Fluorouracil in colorectal cancer, run by Bold Therapeutics, Inc., now recruiting.

## Summary

BOLD-100 in Combination With FOLFOX for the Treatment of Advanced Solid Tumours is a phase 1/2 interventional study registered as NCT04421820 by Bold Therapeutics, Inc., with 220 participants planned, started 2020-08-28 and due to reach its primary completion in 2026-06-01. Interventions recorded: BOLD-100 +/- FOLFOX Chemotherapy (Arm VII), BOLD-100 in combination with FOLFOX Chemotherapy (Arms I-VI). Conditions listed: Colorectal Cancer, Pancreatic Cancer, Gastric Cancers, Cholangiocarcinoma. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-16
- Tags: ctgov-ingest
- Registry id: NCT04421820
- Phase: 1/2
- Setting: A Phase 1b/2a Dose Escalation Study of BOLD-100 in Combination With FOLFOX Chemotherapy in Patients With Advanced Solid Tumours
- Sponsor: Bold Therapeutics, Inc.
- Enrolled: 220

## Sources

- ClinicalTrials.gov NCT04421820: https://clinicaltrials.gov/study/NCT04421820

## Connected records

- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/)
- drugs: [CAPOX (capecitabine, oxaliplatin)](https://onco.cc/drugs/capox/), [FLOT (5-FU, leucovorin, oxaliplatin, docetaxel)](https://onco.cc/drugs/flot/), [Fluorouracil (5-FU)](https://onco.cc/drugs/fluorouracil/), [Leucovorin (folinic acid)](https://onco.cc/drugs/leucovorin/)

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