# Ivermectin plus losartan for COVID-19 in cancer patients (ICESP phase 2, terminated)

Source: https://onco.cc/trials/nct04447235/  
OnCo record `nct04447235` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

This Brazilian trial tested ivermectin against COVID-19 in people with cancer, not against the cancer itself. It was stopped early because an interim analysis found no difference between the drug and placebo.

## Summary

The trial opened on 23 July 2020, planned 176 patients and was terminated after enrolling 77 (ClinicalTrials.gov NCT04447235). The registry gives the reason for stopping as 'futility analysis has demonstrated no difference between arms' (ClinicalTrials.gov NCT04447235). No results are posted and no publication was found on Europe PMC (ClinicalTrials.gov NCT04447235). It appears on this page because it is one of only four ivermectin studies on ClinicalTrials.gov that name cancer, and it says nothing about ivermectin as a cancer treatment (ClinicalTrials.gov NCT04447235).

## Fields

- Kind: Trial
- Status: negative
- Last checked: 2026-09-24
- Registry id: NCT04447235
- Phase: 2
- Setting: Patients with active cancer and newly diagnosed COVID-19: randomised, double-blind, placebo-controlled; a single 12 mg dose of ivermectin then losartan 50 mg daily for 15 days versus placebo; primary endpoint intensive care admission, mechanical ventilation or death within 28 days
- Sponsor: Instituto do Câncer do Estado de São Paulo
- Enrolled: 77
- Result: Terminated for futility after 77 of a planned 176 patients; no difference between arms on the interim analysis, per the registry; no publication (ClinicalTrials.gov NCT04447235).

## Sources

- ClinicalTrials.gov NCT04447235: https://clinicaltrials.gov/study/NCT04447235

## Connected records

- drugs: [Ivermectin](https://onco.cc/drugs/ivermectin/)
- institutions: [Instituto do Câncer do Estado de São Paulo (ICESP)](https://onco.cc/institutions/icesp/)
- terms: [Futility analysis (stopped for futility)](https://onco.cc/terms/futility/)

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