# CompassHER2 RD

Source: https://onco.cc/trials/nct04457596/  
OnCo record `nct04457596` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

CompassHER2 RD compares T-DM1 with or without tucatinib after surgery when cancer remains following pre-surgery therapy. It asks whether adding tucatinib lowers the chance of relapse.

## Summary

CompassHER2 RD compares T-DM1 with or without tucatinib after surgery when cancer remains following pre-surgery therapy. It asks whether adding tucatinib lowers the chance of relapse.

Interventional study registered as NCT04457596, sponsored by Alliance for Clinical Trials in Oncology. Registry phase: 3. Registry enrollment is 1,056 participants (actual). Registry status checked October 10, 2026: active not recruiting. UCSF lists this study as closed to local enrollment; local availability and overall registry status are separate. See the registry for full eligibility and current sites.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-10-10
- Also known as: T-DM1 and Tucatinib Compared With T-DM1 Alone in Preventing Relapses in People With High Risk HER2-Positive Breast Cancer, the CompassHER2 RD Trial
- Tags: ucsf-breast-coverage; interventional
- Registry id: NCT04457596
- Phase: 3
- Setting: High-risk HER2-positive breast cancer with residual disease after pre-surgery treatment
- Sponsor: Alliance for Clinical Trials in Oncology
- Enrolled: 1056

## Sources

- ClinicalTrials.gov NCT04457596: https://clinicaltrials.gov/study/NCT04457596
- UCSF study listing and local availability: https://clinicaltrials.ucsf.edu/trial/NCT04457596

## Connected records

- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/)
- drugs: [Trastuzumab emtansine](https://onco.cc/drugs/trastuzumab-emtansine/), [Tucatinib](https://onco.cc/drugs/tucatinib/)
- institutions: [UCSF Helen Diller Family Comprehensive Cancer Center](https://onco.cc/institutions/ucsf/)

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