# Durvalumab and Tremelimumab in Combination With Chemotherapy in HIV-infected Patients With Non-small Cell Lung Cancer

Source: https://onco.cc/trials/nct04499053/  
OnCo record `nct04499053` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of durvalumab and tremelimumab in lung cancer, run by Georgetown University, now recruiting.

## Summary

Durvalumab and Tremelimumab in Combination With Chemotherapy in HIV-infected Patients With Non-small Cell Lung Cancer is a phase 2, interventional study registered as NCT04499053 by Georgetown University, with a registry enrolment figure of 18 participants, started 2020-12-09 and due to reach its primary completion in 2027-02. Interventions recorded: Durvalumab; Tremelimumab. Conditions listed: Carcinoma, Non-Small Cell Lung. Primary outcome: Adverse Events; Radiological Response. Lung eligibility wording from the registry: "Patients with stage IV NSCLC who had undergone no previous systemic therapy for stage IV disease". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-25
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT04499053
- Phase: 2
- Setting: A Phase II Trial of Durvalumab (MEDI4736) and Tremelimumab in Combination With Chemotherapy in HIV-infected Patients With Non-small Cell Lung Cancer
- Sponsor: Georgetown University
- Enrolled: 18

## Sources

- ClinicalTrials.gov NCT04499053: https://clinicaltrials.gov/study/NCT04499053

## Connected records

- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/)
- drugs: [Durvalumab](https://onco.cc/drugs/durvalumab/), [Tremelimumab](https://onco.cc/drugs/tremelimumab/)
- companies: [AstraZeneca](https://onco.cc/companies/astrazeneca/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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