# Combination of IV Ascorbic Acid and Adebrelimab in Metastatic Colorectal Cancer

Source: https://onco.cc/trials/nct04516681/  
OnCo record `nct04516681` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of adebrelimab in colorectal cancer, run by Fudan University, now recruiting.

## Summary

Combination of IV Ascorbic Acid and Adebrelimab in Metastatic Colorectal Cancer is a phase 3, randomised interventional study registered as NCT04516681 by Fudan University, with a registry enrolment figure of 400 participants, started 2024-12-01 and due to reach its primary completion in 2025-12-01. Interventions recorded: Ascorbic acid; FOLFOX Protocol; Adebrelimab. Conditions listed: Colorectal Cancer; Vitamin C; GLUT3. Primary outcome: Objective Response Rate. Colorectal eligibility wording from the registry: "* Age≥18 years, ≤75 years; Histologically proven peritoneal metastatic adenocarcinoma of colorectal cancer, unresectable metastatic disease; IHC confirmed strong positive GLUT3; measurable disease; Eastern Cooperative Oncology Group (ECOG) performance status 0 to 1; Life expectancy of at least 12 we". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT04516681
- Phase: 3
- Setting: Vitamin C Intravenously With Chemotherapy and Adebrelimab in Metastatic Colorectal Cancer With High Expresison Level of GLUT3
- Sponsor: Fudan University
- Enrolled: 400

## Sources

- ClinicalTrials.gov NCT04516681: https://clinicaltrials.gov/study/NCT04516681

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/)
- drugs: [Adebrelimab](https://onco.cc/drugs/adebrelimab/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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