# PEmbRolizumab verSus chEmotherapy and pEmbrolizumab in Non-small-cell Lung Cancers (NSCLC) With PDL1 ≥ 50 %

Source: https://onco.cc/trials/nct04547504/  
OnCo record `nct04547504` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of pembrolizumab in lung cancer, run by University Hospital, Brest, active but no longer recruiting.

## Summary

PEmbRolizumab verSus chEmotherapy and pEmbrolizumab in Non-small-cell Lung Cancers (NSCLC) With PDL1 ≥ 50 % is a phase 3, randomised interventional study registered as NCT04547504 by University Hospital, Brest, with a registry enrolment figure of 349 participants, started 2020-12-22 and due to reach its primary completion in 2025-12-22. Interventions recorded: Pembrolizumab; Pembrolizumab and Chemotherapy drugs. Conditions listed: Non-small-cell Lung Cancer. Primary outcome: Progression-free survival (PFS) according to RECIST 1.1 assessed by blinded inependant centra review (BICR). Lung eligibility wording from the registry: "Histologically or cytologically confirmed NSCLC". Sites: France. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-25
- Also known as: PERSEE
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT04547504
- Phase: 3
- Setting: Randomized, Open-label, Controlled Phase III Trial Comparing Pembrolizumab-platinum Based Chemotherapy Combination With Pembrolizumab Monotherapy in First Line Treatment of Non-small-cell Lung Cancers (NSCLC) With PDL1 Expression ≥50%
- Sponsor: University Hospital, Brest
- Enrolled: 349

## Sources

- ClinicalTrials.gov NCT04547504: https://clinicaltrials.gov/study/NCT04547504

## Connected records

- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/)
- drugs: [Pembrolizumab](https://onco.cc/drugs/pembrolizumab/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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