# Study of PF-07248144 in Advanced or Metastatic Solid Tumors

Source: https://onco.cc/trials/nct04606446/  
OnCo record `nct04606446` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of PF-07248144, Fulvestrant, Letrozole in prostate cancer and non-small-cell lung cancer, run by Pfizer, now recruiting.

## Summary

Study of PF-07248144 in Advanced or Metastatic Solid Tumors is a phase 2 interventional study registered as NCT04606446 by Pfizer, with 320 participants planned, started 2020-11-16 and due to reach its primary completion in 2029-07-13. Interventions recorded: PF-07248144, Fulvestrant, Letrozole, Palbociclib, PF-07220060. Conditions listed: Locally Advanced or Metastatic ER+ HER2- Breast Cancer, Locally Advanced or Metastatic Castration-resistant Prostate Cancer, Locally Advanced or Metastatic Non-small Cell Lung Cancer. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-16
- Tags: ctgov-ingest
- Registry id: NCT04606446
- Phase: 2
- Setting: A PHASE 1/2A DOSE ESCALATION AND EXPANSION STUDY TO EVALUATE SAFETY, TOLERABILITY, PHARMACOKINETIC, PHARMACODYNAMIC, AND ANTI-TUMOR ACTIVITY OF PF-07248144 IN PARTICIPANTS WITH ADVANCED OR METASTATIC SOLID TUMORS
- Sponsor: Pfizer
- Enrolled: 320

## Sources

- ClinicalTrials.gov NCT04606446: https://clinicaltrials.gov/study/NCT04606446

## Connected records

- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/), [Prostate cancer](https://onco.cc/cancers/prostate/), [Small-cell lung cancer](https://onco.cc/cancers/sclc/)
- drugs: [Atirmociclib](https://onco.cc/drugs/atirmociclib/), [Fulvestrant](https://onco.cc/drugs/fulvestrant/), [Letrozole (and other aromatase inhibitors)](https://onco.cc/drugs/letrozole/), [Palbociclib](https://onco.cc/drugs/palbociclib/), [PF-07248144](https://onco.cc/drugs/pf-07248144/), [Vepdegestrant](https://onco.cc/drugs/vepdegestrant/)
- companies: [Pfizer (incl. Seagen)](https://onco.cc/companies/pfizer/)

---
JSON: https://onco.cc/api/v1/entities/nct04606446.json