# A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors

Source: https://onco.cc/trials/nct04657068/  
OnCo record `nct04657068` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of Gemcitabine, FOLFIRI, Irinotecan in metastatic cancer and ovarian cancer, run by Artios Pharma Ltd, now recruiting.

## Summary

A Study of ART0380 for the Treatment of Advanced or Metastatic Solid Tumors is a phase 1/2 interventional study registered as NCT04657068 by Artios Pharma Ltd, with 542 participants planned, started 2021-01-27 and due to reach its primary completion in 2028-01. Interventions recorded: ART0380, Gemcitabine, Irinotecan. Conditions listed: Advanced Cancer, Metastatic Cancer, Ovarian Cancer, Primary Peritoneal Cancer. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-16
- Tags: ctgov-ingest
- Registry id: NCT04657068
- Phase: 1/2
- Setting: A Phase I/IIa, Open-label, Multi-center Study to Assess the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of the ATR Kinase Inhibitor ART0380 Administered Orally as Monotherapy and in Combination to Patients With Advanced or Metastatic Solid Tumors
- Sponsor: Artios Pharma Ltd
- Enrolled: 542

## Sources

- ClinicalTrials.gov NCT04657068: https://clinicaltrials.gov/study/NCT04657068

## Connected records

- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Endometrial cancer](https://onco.cc/cancers/endometrial/), [Metastatic cancer (cancer that has spread)](https://onco.cc/cancers/metastatic-cancer/), [Ovarian cancer](https://onco.cc/cancers/ovarian/), [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/)
- drugs: [FOLFIRI (5-FU, leucovorin, irinotecan)](https://onco.cc/drugs/folfiri/), [Gemcitabine](https://onco.cc/drugs/gemcitabine/), [Irinotecan (and liposomal irinotecan)](https://onco.cc/drugs/irinotecan/)

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