# Denosumab for breast cancer prevention in BRCA1 carriers

Source: https://onco.cc/trials/nct04711109/  
OnCo record `nct04711109` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

This study compares denosumab with placebo to see whether it prevents breast cancer in women with an inherited BRCA1 mutation. It is a prevention study rather than treatment for diagnosed cancer.

## Summary

This study compares denosumab with placebo to see whether it prevents breast cancer in women with an inherited BRCA1 mutation. It is a prevention study rather than treatment for diagnosed cancer.

Interventional study registered as NCT04711109, sponsored by Alliance for Clinical Trials in Oncology. Registry phase: 3. Registry enrollment is 300 participants (estimated). Registry status checked October 10, 2026: active not recruiting. UCSF lists this study as closed to local enrollment; local availability and overall registry status are separate. See the registry for full eligibility and current sites.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-10-10
- Also known as: Studying the Effect of Denosumab on Preventing Breast Cancer in Women With a BRCA1 Germline Mutation
- Tags: ucsf-breast-coverage; interventional
- Registry id: NCT04711109
- Phase: 3
- Setting: Breast cancer prevention in women with a germline BRCA1 mutation
- Sponsor: Alliance for Clinical Trials in Oncology

## Sources

- ClinicalTrials.gov NCT04711109: https://clinicaltrials.gov/study/NCT04711109
- UCSF study listing and local availability: https://clinicaltrials.ucsf.edu/trial/NCT04711109

## Connected records

- cancers: [Breast cancer (all types)](https://onco.cc/cancers/breast-cancer/)
- drugs: [Denosumab](https://onco.cc/drugs/denosumab/)
- institutions: [UCSF Helen Diller Family Comprehensive Cancer Center](https://onco.cc/institutions/ucsf/)

---
JSON: https://onco.cc/api/v1/entities/nct04711109.json