# Study Evaluating Effectiveness and Safety of Zimberelimab and Domvanalimab in Lung Cancer

Source: https://onco.cc/trials/nct04736173/  
OnCo record `nct04736173` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of Domvanalimab, Zimberelimab, Carboplatin in non-small-cell lung cancer and small-cell lung cancer, run by Arcus Biosciences, Inc., active and no longer recruiting.

## Summary

Study Evaluating Effectiveness and Safety of Zimberelimab and Domvanalimab in Lung Cancer is a phase 2 interventional study registered as NCT04736173 by Arcus Biosciences, Inc., with 169 participants enrolled, started 2021-02-08 and due to reach its primary completion in 2027-05. Interventions recorded: Domvanalimab, Zimberelimab, Carboplatin, Paclitaxel, Pemetrexed. Conditions listed: Non Small Cell Lung Cancer, Nonsquamous Non Small Cell Lung Cancer, Squamous Non Small Cell Lung Cancer, Lung Cancer. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-16
- Tags: ctgov-ingest
- Registry id: NCT04736173
- Phase: 2
- Setting: Official Title: A Phase 2 Study to Evaluate Zimberelimab (AB122) Combined With AB154 in Front-Line, PD-L1-High, Locally Advanced or Metastatic Non-Small Cell Lung Cancer
- Sponsor: Arcus Biosciences, Inc.
- Enrolled: 169

## Sources

- ClinicalTrials.gov NCT04736173: https://clinicaltrials.gov/study/NCT04736173

## Connected records

- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/), [Small-cell lung cancer](https://onco.cc/cancers/sclc/)
- drugs: [Carboplatin](https://onco.cc/drugs/carboplatin/), [Domvanalimab](https://onco.cc/drugs/domvanalimab/), [Paclitaxel / nab-paclitaxel](https://onco.cc/drugs/paclitaxel/), [Pembrolizumab](https://onco.cc/drugs/pembrolizumab/), [Pemetrexed](https://onco.cc/drugs/pemetrexed/), [Zimberelimab](https://onco.cc/drugs/zimberelimab/)
- companies: [Arcus Biosciences](https://onco.cc/companies/arcus-biosciences/)

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JSON: https://onco.cc/api/v1/entities/nct04736173.json