# Study Evaluating the Tailored Management of Locally-advanced Rectal Carcinoma

Source: https://onco.cc/trials/nct04749108/  
OnCo record `nct04749108` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2/3 trial in colorectal cancer, run by Institut du Cancer de Montpellier - Val d'Aurelle, now recruiting.

## Summary

Study Evaluating the Tailored Management of Locally-advanced Rectal Carcinoma is a phase 2/3, randomised interventional study registered as NCT04749108 by Institut du Cancer de Montpellier - Val d'Aurelle, with a registry enrolment figure of 1075 participants, started 2021-11-26 and due to reach its primary completion in 2029-09. Interventions recorded: Induction chemotherapy - modified FOLFIRINOX regimen; Early tumor response evaluation by MRI volumetry; Radiochemotherapy Cap 50; Radical proctectomy with total mesorectal excision. Conditions listed: Locally Advanced Malignant Neoplasm; Rectal Carcinoma. Primary outcome: R0 resection rate (R0 is defined as Circumferential resection margin (CRM ≥ 1 mm) for Phase II; 3-year Disease free survival (DFS) for Phase III. Colorectal eligibility wording from the registry: "Histologically confirmed diagnosis of adenocarcinoma of the rectum,". Sites: France. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: GRECCAR14
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT04749108
- Phase: 2/3
- Setting: Multicentric Phase II-III Study Evaluating the Tailored Management of Locally-advanced Rectal Carcinoma After a Favorable Response to Induction Chemotherapy
- Sponsor: Institut du Cancer de Montpellier - Val d'Aurelle
- Enrolled: 1075

## Sources

- ClinicalTrials.gov NCT04749108: https://clinicaltrials.gov/study/NCT04749108

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct04749108.json