# Nano-SMART: Nanoparticles With MR Guided SBRT in Centrally Located Lung Tumors and Pancreatic Cancer

Source: https://onco.cc/trials/nct04789486/  
OnCo record `nct04789486` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial in pancreatic cancer, run by Dana-Farber Cancer Institute, now recruiting.

## Summary

Nano-SMART: Nanoparticles With MR Guided SBRT in Centrally Located Lung Tumors and Pancreatic Cancer is a phase 1/2, randomised interventional study registered as NCT04789486 by Dana-Farber Cancer Institute, with a registry enrolment figure of 100 participants, started 2021-05-27 and due to reach its primary completion in 2028-04-10. Interventions recorded: AGuIX; Radiotherapy. Conditions listed: Non-small Cell Lung Cancer; Advanced Pancreatic Adenocarcinoma; Unresectable Pancreatic Cancer; Ductal Adenocarcinoma of the Pancreas. Primary outcome: Maximum tolerated dose (MTD) Phase 1; Compare Local Control at 12 months of Maximum tolerated dose MTD - Phase 2. Pancreatic eligibility wording from the registry: "OR Histologically or cytologically confirmed pancreatic ductal adenocarcinoma of the pancreatic head, body or tail". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; pancreatic-deep-dive
- Registry id: NCT04789486
- Phase: 1/2
- Setting: Nano-SMART: An Adaptive Phase I-II Trial of AGuIX Gadolinium-based Nanoparticles With Stereotactic Magnetic Resonance-guided Adaptive Radiation Therapy for Centrally Located Lung Tumors and Locally Advanced Unresectable Pancreatic Ductal Adenocarcinoma
- Sponsor: Dana-Farber Cancer Institute
- Enrolled: 100

## Sources

- ClinicalTrials.gov NCT04789486: https://clinicaltrials.gov/study/NCT04789486

## Connected records

- cancers: [Locally advanced unresectable pancreatic ductal adenocarcinoma](https://onco.cc/cancers/locally-advanced-pdac/)
- technologies: [SBRT / SABR (stereotactic radiotherapy)](https://onco.cc/technologies/sbrt/)
- terms: [Pancreatic cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/pancreatic-trials-open-today/)

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