# Efficacy and Safety of Prophylactic Cranial Irradiation Versus MRI Surveillance in Patients With Limited-stage Small Cell Lung Cancer Who Achieved Remission Aft

Source: https://onco.cc/trials/nct04829708/  
OnCo record `nct04829708` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in lung cancer, run by Shandong Cancer Hospital and Institute, now recruiting.

## Summary

Efficacy and Safety of Prophylactic Cranial Irradiation Versus MRI Surveillance in Patients With Limited-stage Small Cell Lung Cancer Who Achieved Remission After First-line Chemoradiotherapy is a phase 3, randomised interventional study registered as NCT04829708 by Shandong Cancer Hospital and Institute, with a registry enrolment figure of 534 participants, started 2021-04-26 and due to reach its primary completion in 2026-04-15. Interventions recorded: MRI Surveillance; Prophylactic Cranial Irradiation. Conditions listed: Limited Stage Small Cell Lung Cancer. Primary outcome: Overall survival (OS). Lung eligibility wording from the registry: "Histological or cytological confirmation of LS-SCLC before first-line chemoradiotherapy (according to the staging system of the Veterans' Affairs Lung Study Group (VALSG), Appendix 2)；". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-25
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT04829708
- Phase: 3
- Setting: Efficacy and Safety of Prophylactic Cranial Irradiation Versus MRI Surveillance in Patients With Limited-stage Small Cell Lung Cancer Who Achieved Remission After First-line Chemoradiotherapy: a Multicenter Randomized Controlled Phase III Clinical Trial
- Sponsor: Shandong Cancer Hospital and Institute
- Enrolled: 534

## Sources

- ClinicalTrials.gov NCT04829708: https://clinicaltrials.gov/study/NCT04829708

## Connected records

- cancers: [Limited-stage small-cell lung cancer](https://onco.cc/cancers/limited-stage-sclc/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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