# Efficacy of Hyperthermic Intraperitoneal Chemotherapy

Source: https://onco.cc/trials/nct04861558/  
OnCo record `nct04861558` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of fOLFIRI (5-FU, leucovorin, irinotecan) and fOLFOX (5-FU, leucovorin, oxaliplatin) in colorectal cancer, run by Uppsala University, now recruiting.

## Summary

Efficacy of Hyperthermic Intraperitoneal Chemotherapy is a phase 3, randomised interventional study registered as NCT04861558 by Uppsala University, with a registry enrolment figure of 213 participants, started 2021-05-01 and due to reach its primary completion in 2025-12. Interventions recorded: 5Fluorouracil; Irinotecan; Oxaliplatin. Conditions listed: Colorectal Cancer; Peritoneal Metastases. Primary outcome: Recurrence-free survival. Colorectal eligibility wording from the registry: "Colorectal cancer with peritoneal metastases +/- liver metastases (maximum 3)". Sites: India, Sweden. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: EFFIPEC
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT04861558
- Phase: 3
- Setting: EFFIPEC - Efficacy of Hyperthermic Intraperitoneal Chemotherapy, Single-arm Phase I Study, Followed by an Open-label, Randomized, Controlled Registry-based Phase III Trial
- Sponsor: Uppsala University
- Enrolled: 213

## Sources

- ClinicalTrials.gov NCT04861558: https://clinicaltrials.gov/study/NCT04861558

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [HIPEC / PIPAC (intraperitoneal chemotherapy)](https://onco.cc/technologies/hipec/), [Platinum agents](https://onco.cc/technologies/platinum/), [Topoisomerase-I inhibitors (and ADC payloads)](https://onco.cc/technologies/topoisomerase-inhibitors/)
- drugs: [FOLFIRI (5-FU, leucovorin, irinotecan)](https://onco.cc/drugs/folfiri/), [FOLFOX (5-FU, leucovorin, oxaliplatin)](https://onco.cc/drugs/folfox/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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