# Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combina

Source: https://onco.cc/trials/nct04868877/  
OnCo record `nct04868877` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of MCLA-129, Osimertinib in non-small-cell lung cancer and small-cell lung cancer, run by Merus B.V., active and no longer recruiting.

## Summary

Phase 1/2 Study Evaluating MCLA-129, a Human Anti-EGFR, Anti-c-MET Bispecific Antibody, in Advanced NSCLC and Other Solid Tumors, Alone and in Combination is a phase 1/2 interventional study registered as NCT04868877 by Merus B.V., with 194 participants enrolled, started 2021-04-28 and due to reach its primary completion in 2026-03. Interventions recorded: MCLA-129, Osimertinib, Chemotherapy. Conditions listed: Non-Small Cell Lung Cancer Metastatic, Gastric Cancer, Esophageal Squamous Cell Carcinoma, Head and Neck Squamous Cell Carcinoma. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-16
- Tags: ctgov-ingest
- Registry id: NCT04868877
- Phase: 1/2
- Setting: Phase 1/2 Dose Escalation and Expansion Study Evaluating MCLA-129, a Human Anti-EGFR and Anti-c-MET Bispecific Antibody, in Patients With Advanced NSCLC and Other Solid Tumors
- Sponsor: Merus B.V.
- Enrolled: 194

## Sources

- ClinicalTrials.gov NCT04868877: https://clinicaltrials.gov/study/NCT04868877

## Connected records

- cancers: [Colorectal cancer](https://onco.cc/cancers/colorectal/), [Head and neck squamous cell carcinoma](https://onco.cc/cancers/head-and-neck/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/), [Small-cell lung cancer](https://onco.cc/cancers/sclc/)
- drugs: [MCLA-129](https://onco.cc/drugs/mcla-129/), [Osimertinib](https://onco.cc/drugs/osimertinib/)
- companies: [Genmab](https://onco.cc/companies/genmab/)

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