# Temozolomide and Atezolizumab for Subsequent Line for the Treatment of Metastatic or Recurrent Small Cell Lung Cancer

Source: https://onco.cc/trials/nct04919382/  
OnCo record `nct04919382` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of atezolizumab and temozolomide in lung cancer, run by Dwight Owen, now recruiting.

## Summary

Temozolomide and Atezolizumab for Subsequent Line for the Treatment of Metastatic or Recurrent Small Cell Lung Cancer is a phase 2, randomised interventional study registered as NCT04919382 by Dwight Owen, with a registry enrolment figure of 56 participants, started 2022-01-26 and due to reach its primary completion in 2027-12-30. Interventions recorded: Atezolizumab; Temozolomide. Conditions listed: Extensive Stage Lung Small Cell Carcinoma; Metastatic Lung Small Cell Carcinoma; Recurrent Lung Small Cell Carcinoma; Stage IV Lung Cancer AJCC v8; Stage IVA Lung Cancer AJCC v8; Stage IVB Lung Cancer AJCC v8. Primary outcome: Investigator-assessed objective response rate (ORR). Lung eligibility wording from the registry: "metastatic and/or recurrent) small cell lung cancer and have progressed or recurred after platinum-based chemotherapy with immunotherapy". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-25
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT04919382
- Phase: 2
- Setting: A Randomized, Multi-Cohort Phase II Trial of Temozolomide and Atezolizumab for Subsequent Line Treatment for Small Cell Lung Cancer
- Sponsor: Dwight Owen
- Enrolled: 56

## Sources

- ClinicalTrials.gov NCT04919382: https://clinicaltrials.gov/study/NCT04919382

## Connected records

- cancers: [Extensive-stage small-cell lung cancer](https://onco.cc/cancers/extensive-stage-sclc/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/)
- drugs: [Atezolizumab](https://onco.cc/drugs/atezolizumab/), [Temozolomide](https://onco.cc/drugs/temozolomide/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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