# Comparison of the Pathological Effect Between 2 and 4 Cycles Neoadjuvant CAPOX for Low/Intermediate Risk II/III Rectal Cancer

Source: https://onco.cc/trials/nct04922853/  
OnCo record `nct04922853` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in colorectal cancer, run by West China Hospital, active but no longer recruiting.

## Summary

Comparison of the Pathological Effect Between 2 and 4 Cycles Neoadjuvant CAPOX for Low/Intermediate Risk II/III Rectal Cancer is a phase 3, randomised interventional study registered as NCT04922853 by West China Hospital, with a registry enrolment figure of 554 participants, started 2021-08-26 and due to reach its primary completion in 2024-10-01. Interventions recorded: Capox chemotherapy. Conditions listed: Rectal Cancer; Neoadjuvant Chemotherapy. Primary outcome: pathological Tumor Regression Grade evaluation. Colorectal eligibility wording from the registry: "Patients diagnosed with low/intermediate risk stage II/III rectal cancer under MRI and transanal ultrasound,defined as: low:T3a-bN0-1M0, EMVI (±), MRF (-) (≥2mm); Middle-high rectal cancer: T3a-cN0-1M0, EMVI (±), MRF (-) (≥2mm); No more than 3 lymph nodes with short diameter over 8mm or highly suspe". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-24
- Also known as: COPEC
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT04922853
- Phase: 3
- Setting: Comparison of the Pathological Effect Between 2 and 4 Cycles Neoadjuvant CAPOX for Low/Intermediate Risk II/III Rectal Cancer：a Prospective, Non-inferior, Randomized, Controlled Trial
- Sponsor: West China Hospital
- Enrolled: 554

## Sources

- ClinicalTrials.gov NCT04922853: https://clinicaltrials.gov/study/NCT04922853

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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