# A Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors

Source: https://onco.cc/trials/nct04931342/  
OnCo record `nct04931342` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of Ipatasertib, Cobimetinib, Trastuzumab emtansine in ovarian cancer, run by Hoffmann-La Roche, active and no longer recruiting.

## Summary

A Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors is a phase 2 interventional study registered as NCT04931342 by Hoffmann-La Roche, with 176 participants enrolled, started 2021-10-07 and due to reach its primary completion in 2028-02-28. Interventions recorded: Ipatasertib, Cobimetinib, Trastuzumab Emtansine, Atezolizumab, Bevacizumab. Conditions listed: Ovarian Cancer. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-16
- Tags: ctgov-ingest
- Registry id: NCT04931342
- Phase: 2
- Setting: A Phase II, Open-Label, Multicenter, Platform Study Evaluating the Efficacy and Safety of Biomarker-Driven Therapies in Patients With Persistent or Recurrent Rare Epithelial Ovarian Tumors
- Sponsor: Hoffmann-La Roche
- Enrolled: 176

## Sources

- ClinicalTrials.gov NCT04931342: https://clinicaltrials.gov/study/NCT04931342

## Connected records

- cancers: [Ovarian cancer](https://onco.cc/cancers/ovarian/)
- drugs: [Atezolizumab](https://onco.cc/drugs/atezolizumab/), [Bevacizumab](https://onco.cc/drugs/bevacizumab/), [Cobimetinib](https://onco.cc/drugs/cobimetinib/), [Ipatasertib](https://onco.cc/drugs/ipatasertib/), [Paclitaxel / nab-paclitaxel](https://onco.cc/drugs/paclitaxel/), [Trastuzumab emtansine](https://onco.cc/drugs/trastuzumab-emtansine/)
- companies: [Roche / Genentech](https://onco.cc/companies/roche-genentech/)

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JSON: https://onco.cc/api/v1/entities/nct04931342.json