# BrUOG 397: NEO Rad (LOW): Neoadjuvant Low Dose Stereotactic Body Radiotherapy, Ipilimumab and Nivolumab

Source: https://onco.cc/trials/nct04933903/  
OnCo record `nct04933903` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of ipilimumab and nivolumab in lung cancer, run by Brown University, now recruiting.

## Summary

BrUOG 397: NEO Rad (LOW): Neoadjuvant Low Dose Stereotactic Body Radiotherapy, Ipilimumab and Nivolumab is a phase 2, interventional study registered as NCT04933903 by Brown University, with a registry enrolment figure of 25 participants, started 2021-10-05 and due to reach its primary completion in 2026-10. Interventions recorded: Ipilimumab; Nivolumab; SBRT. Conditions listed: Non Small Cell Lung Cancer. Primary outcome: Number of Patients with a Pathologic Response. Lung eligibility wording from the registry: "Pathologically confirmed NSCLC". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-25
- Tags: ctgov-ingest; lung-deep-dive
- Registry id: NCT04933903
- Phase: 2
- Setting: BrUOG 397: NEO Rad (LOW): Neoadjuvant Low Dose Stereotactic Body Radiotherapy, Ipilimumab and Nivolumab for Patients With Resectable Stage IB - III Non-Small Cell Lung Cancer
- Sponsor: Brown University
- Enrolled: 25

## Sources

- ClinicalTrials.gov NCT04933903: https://clinicaltrials.gov/study/NCT04933903

## Connected records

- cancers: [Resectable stage I to III non-small-cell lung cancer](https://onco.cc/cancers/resectable-nsclc/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/), [SBRT / SABR (stereotactic radiotherapy)](https://onco.cc/technologies/sbrt/)
- drugs: [Ipilimumab](https://onco.cc/drugs/ipilimumab/), [Nivolumab](https://onco.cc/drugs/nivolumab/)
- companies: [Bristol Myers Squibb](https://onco.cc/companies/bms/)
- terms: [Lung cancer trials open today (registry snapshot)](https://onco.cc/terms/lung-trials-open-today/)

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