# Seviteronel in Combination With Chemotherapy in Androgen-receptor Positive Metastatic Triple-negative Breast Cancer

Source: https://onco.cc/trials/nct04947189/  
OnCo record `nct04947189` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of dexamethasone and docetaxel in triple-negative breast cancer, run by St Vincent's Hospital, Sydney, now recruiting.

## Summary

Seviteronel in Combination With Chemotherapy in Androgen-receptor Positive Metastatic Triple-negative Breast Cancer is a phase 1/2, interventional study registered as NCT04947189 by St Vincent's Hospital, Sydney, with a registry enrolment figure of 65 participants, started 2022-11-01 and due to reach its primary completion in 2026-07. Interventions recorded: Seviteronel-D (Seivteronel in combination with dexamethasone); Docetaxel. Conditions listed: Triple Negative Breast Cancer. Triple-negative eligibility wording from the registry: ", IHC 3+ or in situ hybridisation (ISH) positive according to standard ASCO/CAP guidelines or triple-negative breast cancer, i". Sites: Australia. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: 4CAST
- Tags: ctgov-ingest; tnbc-deep-dive
- Registry id: NCT04947189
- Phase: 1/2
- Setting: 4CAST: A Phase 1b Dose Exploration and Dose Expansion, Open-label, Single-centre Study Evaluating the Safety and Efficacy of INO-464 in Combination With Chemotherapy in Patients With metASTatic Breast Cancer
- Sponsor: St Vincent's Hospital, Sydney
- Enrolled: 65

## Sources

- ClinicalTrials.gov NCT04947189: https://clinicaltrials.gov/study/NCT04947189

## Connected records

- cancers: [Metastatic triple-negative breast cancer](https://onco.cc/cancers/tnbc-metastatic/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/)
- drugs: [Dexamethasone](https://onco.cc/drugs/dexamethasone/), [Docetaxel](https://onco.cc/drugs/docetaxel/)
- terms: [Triple-negative breast cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/tnbc-trials-open-today/)

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