# EUS-RFA PANCARDINAL-1 Trial

Source: https://onco.cc/trials/nct04990609/  
OnCo record `nct04990609` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in pancreatic cancer, run by The University of Texas Health Science Center, Houston, now recruiting.

## Summary

EUS-RFA PANCARDINAL-1 Trial is a phase 2, interventional study registered as NCT04990609 by The University of Texas Health Science Center, Houston, with a registry enrolment figure of 60 participants, started 2021-08-13 and due to reach its primary completion in 2026-12-01. Interventions recorded: Endoscopic Ultrasound (EUS)-Guided Radiofrequency Ablation (RFA); Neoadjuvant Chemotherapy (NAC). Conditions listed: Pancreatic Ductal Adenocarcinoma (PDAC). Primary outcome: Number of participants who are able to complete neoadjuvant chemotherapy plus EUS-RFA and later undergo surgical tumor resection. Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; pancreatic-deep-dive
- Registry id: NCT04990609
- Phase: 2
- Setting: A Single-arm Phase II Study to Evaluate the Safety and Efficacy of Combination Systematic Chemotherapy and Multiple Rounds of Endoscopic Ultrasound-guided Radiofrequency Ablation in Pancreatic Cancer
- Sponsor: The University of Texas Health Science Center, Houston
- Enrolled: 60

## Sources

- ClinicalTrials.gov NCT04990609: https://clinicaltrials.gov/study/NCT04990609

## Connected records

- cancers: [Pancreatic ductal adenocarcinoma](https://onco.cc/cancers/pancreatic/)
- terms: [Pancreatic cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/pancreatic-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct04990609.json