# Trifluridine/ Tipiracil Plus Panitumumab Versus Trifluridine/ Tipiracil Plus Bevacizumab as First-line Treatment of Metastatic Colorectal Cancer

Source: https://onco.cc/trials/nct05007132/  
OnCo record `nct05007132` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of bevacizumab (glioblastoma use) in colorectal cancer, run by Dominik Paul Modest, now recruiting.

## Summary

Trifluridine/ Tipiracil Plus Panitumumab Versus Trifluridine/ Tipiracil Plus Bevacizumab as First-line Treatment of Metastatic Colorectal Cancer is a phase 2, randomised interventional study registered as NCT05007132 by Dominik Paul Modest, with a registry enrolment figure of 153 participants, started 2021-12-17 and due to reach its primary completion in 2029-12. Interventions recorded: Panitumumab 20 milligram/ML; Bevacizumab; Trifluridine/Tipiracil Hydrochloride. Conditions listed: Metastatic Colorectal Cancer. Primary outcome: Objective response rate. Colorectal eligibility wording from the registry: "Histologically confirmed adenocarcinoma of the colon or rectum". Sites: Germany. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05007132
- Phase: 2
- Setting: Prospective, Randomized, Open, Multicenter Phase II Trial to Investigate the Efficacy of Trifluridine/Tipiracil Plus Panitumumab Versus Trifluridine/Tipiracil Plus Bevacizumab as First-line Treatment of Metastatic Colorectal Cancer: FIRE-8; AIO-KRK/YMO-0519
- Sponsor: Dominik Paul Modest
- Enrolled: 153

## Sources

- ClinicalTrials.gov NCT05007132: https://clinicaltrials.gov/study/NCT05007132

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- drugs: [Bevacizumab (glioblastoma use)](https://onco.cc/drugs/bevacizumab-glioma/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct05007132.json