# Post-resection/Ablation Chemotherapy in Patients With Metastatic Colorectal Cancer (FIRE-9 - PORT / AIO-KRK-0418)

Source: https://onco.cc/trials/nct05008809/  
OnCo record `nct05008809` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of fOLFOX (5-FU, leucovorin, oxaliplatin), FOLFOXIRI, fOLFIRI (5-FU, leucovorin, irinotecan) and cAPOX (capecitabine, oxaliplatin) in colorectal cancer, run by Dominik Paul Modest, now recruiting.

## Summary

Post-resection/Ablation Chemotherapy in Patients With Metastatic Colorectal Cancer (FIRE-9 - PORT / AIO-KRK-0418) is a phase 3, randomised interventional study registered as NCT05008809 by Dominik Paul Modest, with a registry enrolment figure of 507 participants, started 2021-12-06 and due to reach its primary completion in 2027-11. Interventions recorded: mFOLFOX6; mFOLFOXIRI; FOLFIRI; CAPOX. Conditions listed: Colorectal Cancer. Primary outcome: Progression-free survival (PFS) time. Colorectal eligibility wording from the registry: "Histologically confirmed adenocarcinoma of the colon or rectum". Sites: Germany. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05008809
- Phase: 3
- Setting: Post-resection/Ablation Chemotherapy in Patients With Metastatic Colorectal Cancer Prospective, Randomized, Open, Multicenter Phase III Trial to Investigate the Efficacy of Active Post-resection/Ablation Therapy in Patients With Metastatic Colorectal Cancer
- Sponsor: Dominik Paul Modest
- Enrolled: 507

## Sources

- ClinicalTrials.gov NCT05008809: https://clinicaltrials.gov/study/NCT05008809

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Platinum agents](https://onco.cc/technologies/platinum/), [Thermal ablation (RFA, microwave, cryo)](https://onco.cc/technologies/thermal-ablation/), [Topoisomerase-I inhibitors (and ADC payloads)](https://onco.cc/technologies/topoisomerase-inhibitors/)
- drugs: [CAPOX (capecitabine, oxaliplatin)](https://onco.cc/drugs/capox/), [FOLFIRI (5-FU, leucovorin, irinotecan)](https://onco.cc/drugs/folfiri/), [FOLFOX (5-FU, leucovorin, oxaliplatin)](https://onco.cc/drugs/folfox/), [FOLFOXIRI (5-FU, leucovorin, oxaliplatin, irinotecan)](https://onco.cc/drugs/folfoxiri/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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