# Cryoablation Combined with Sintilimab Plus Regorafenib in Previously Treated Colorectal Cancer Liver Metastasis

Source: https://onco.cc/trials/nct05057052/  
OnCo record `nct05057052` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of sintilimab and regorafenib in colorectal cancer, run by Fudan University, now recruiting.

## Summary

Cryoablation Combined with Sintilimab Plus Regorafenib in Previously Treated Colorectal Cancer Liver Metastasis is a phase 2, interventional study registered as NCT05057052 by Fudan University, with a registry enrolment figure of 25 participants, started 2021-09-26 and due to reach its primary completion in 2026-09-25. Interventions recorded: Sintilimab; Regorafenib; US/CT-guided Percutaneous Cryoablation. Conditions listed: Liver Metastases; Colorectal Cancer Metastatic. Primary outcome: Objective Response Rate (ORR). Colorectal eligibility wording from the registry: "* Participants must have colorectal cancer liver metastasis". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05057052
- Phase: 2
- Setting: A Phase II Study of Cryoablation Combined with Sintilimab Plus Regorafenib in Previously Treated Colorectal Cancer Liver Metastasis (CASTLE-03)
- Sponsor: Fudan University
- Enrolled: 25

## Sources

- ClinicalTrials.gov NCT05057052: https://clinicaltrials.gov/study/NCT05057052

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Anti-angiogenic therapy](https://onco.cc/technologies/antiangiogenic/), [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/), [Small-molecule kinase inhibitors](https://onco.cc/technologies/kinase-inhibitors/), [Thermal ablation (RFA, microwave, cryo)](https://onco.cc/technologies/thermal-ablation/)
- drugs: [Regorafenib](https://onco.cc/drugs/regorafenib/), [Sintilimab](https://onco.cc/drugs/sintilimab/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct05057052.json