# Efficacy and Safety of TPIAT for Resectable Adenocarcinoma of the Pancreas Region at High Risk of Postoperative Fistula

Source: https://onco.cc/trials/nct05116072/  
OnCo record `nct05116072` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial in pancreatic cancer, run by University Hospital, Lille, now recruiting.

## Summary

Efficacy and Safety of TPIAT for Resectable Adenocarcinoma of the Pancreas Region at High Risk of Postoperative Fistula is a phase 1/2, interventional study registered as NCT05116072 by University Hospital, Lille, with a registry enrolment figure of 36 participants, started 2022-02-20 and due to reach its primary completion in 2028-02-20. Interventions recorded: total pancreatectomy; intraportal islet autotransplantation. Conditions listed: Adenocarcinoma of the Pancreas; Adenocarcinoma of the Duodenum; Ampullary Adenocarcinoma. Primary outcome: the rate of patients who have completed the chemotherapy planned. Pancreatic eligibility wording from the registry: "Inclusion criteria are composed of preoperative conditions validated by intraoperative confirmation to plan an exit of the protocol if the pancreas does not finally appear with a high-risk of CR-POPF". Sites: France. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: TPIAT-01
- Tags: ctgov-ingest; pancreatic-deep-dive
- Registry id: NCT05116072
- Phase: 1/2
- Setting: Efficacy and Safety of Total Pancreatectomy With Intraportal Islet Autotransplantation for Resectable Adenocarcinoma of the Cephalic Region of the Pancreas at High-risk of Postoperative Fistula and Requiring Systemic Adjuvant Chemotherapy
- Sponsor: University Hospital, Lille
- Enrolled: 36

## Sources

- ClinicalTrials.gov NCT05116072: https://clinicaltrials.gov/study/NCT05116072

## Connected records

- cancers: [Resectable pancreatic ductal adenocarcinoma](https://onco.cc/cancers/resectable-pdac/)
- terms: [Pancreatic cancer trials open today (registry snapshot and UK sites)](https://onco.cc/terms/pancreatic-trials-open-today/)

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