# Neoadjuvant and Adjuvant Therapy Studies of Sindilizumab in Resectable Lung Cancer

Source: https://onco.cc/trials/nct05116462/  
OnCo record `nct05116462` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of Pemetrexed, Carboplatin, Paclitaxel / nab-paclitaxel in non-small-cell lung cancer and small-cell lung cancer, run by Innovent Biologics (Suzhou) Co. Ltd., active and no longer recruiting.

## Summary

Neoadjuvant and Adjuvant Therapy Studies of Sindilizumab in Resectable Lung Cancer is a phase 3 interventional study registered as NCT05116462 by Innovent Biologics (Suzhou) Co. Ltd., with 506 participants enrolled, started 2024-03-15 and due to reach its primary completion in 2026-09-30. Interventions recorded: Pemetrexed, Carboplatin, Paclitaxel, Sintilimab, Cisplatin. Conditions listed: Non-Small Cell Lung Cancer. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-16
- Tags: ctgov-ingest
- Registry id: NCT05116462
- Phase: 3
- Setting: A Randomized, Double-blind, Phase 3 Study of the Efficacy and Safety of Sindilizumab Combined With Chemotherapy or Placebo Combined With Chemotherapy for Neoadjuvant and Adjuvant Therapy for Resectable Non-small Cell Lung Cancer (ORIENT-99)
- Sponsor: Innovent Biologics (Suzhou) Co. Ltd.
- Enrolled: 506

## Sources

- ClinicalTrials.gov NCT05116462: https://clinicaltrials.gov/study/NCT05116462

## Connected records

- cancers: [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/), [Small-cell lung cancer](https://onco.cc/cancers/sclc/)
- drugs: [Carboplatin](https://onco.cc/drugs/carboplatin/), [Cisplatin](https://onco.cc/drugs/cisplatin/), [Paclitaxel / nab-paclitaxel](https://onco.cc/drugs/paclitaxel/), [Pemetrexed](https://onco.cc/drugs/pemetrexed/), [Sintilimab](https://onco.cc/drugs/sintilimab/)
- companies: [Innovent Biologics](https://onco.cc/companies/innovent/)

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