# A Study of NKT2152, a HIF2α Inhibitor, in Patients With Advanced Clear Cell Renal Cell Carcinoma

Source: https://onco.cc/trials/nct05119335/  
OnCo record `nct05119335` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of NKT2152 run by NiKang Therapeutics, Inc., terminated.

## Summary

A Study of NKT2152, a HIF2α Inhibitor, in Patients With Advanced Clear Cell Renal Cell Carcinoma is a phase 1/2 interventional study registered as NCT05119335 by NiKang Therapeutics, Inc., with 120 participants enrolled, started 2021-10-26, primary completion reached 2025-08-22. Conditions recorded: ccRCC, Clear Cell Renal Cell Carcinoma, Kidney Cancer, Kidney Neoplasms, Renal Cancer, Renal Neoplasms, Recurrent Renal Cell Carcinoma, Metastatic Renal Cell Carcinoma, Refractory Renal Cell Carcinoma, Advanced Renal Cell Carcinoma, Hypoxia, Renal Cell Carcinoma, Hypoxia Inducible Factor (HIF), HIF2α Inhibitor, Hypoxia Inducible Factor 2 Alpha (HIF-2 Alpha), Hypoxia Inducible Factor 2α (HIF-2α), Clear Cell. Interventions recorded: Oral NKT2152. Reason given for stopping: This study was terminated as a result of Sponsor portfolio reprioritization.

## Fields

- Kind: Trial
- Status: historic
- Last checked: 2026-11-04
- Tags: pipeline; ctgov-ingest
- Registry id: NCT05119335
- Phase: 1/2
- Setting: Phase 1/2 Open Label Dose-escalation and Expansion Trial of NKT2152 an Orally Administered HIF2α Inhibitor to Investigate Safety Pharmacokinetics Pharmacodynamics and Clinical Activity in Patients With Advanced Clear Cell Renal Cell Carcinoma
- Sponsor: NiKang Therapeutics, Inc.
- Enrolled: 120

## Sources

- ClinicalTrials.gov NCT05119335: https://clinicaltrials.gov/study/NCT05119335

## Connected records

- cancers: [Clear cell renal cell carcinoma](https://onco.cc/cancers/clear-cell-rcc/)
- drugs: [NKT2152](https://onco.cc/drugs/nkt2152/)
- companies: [NiKang Therapeutics](https://onco.cc/companies/nikang-therapeutics/)

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