# A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies

Source: https://onco.cc/trials/nct05123482/  
OnCo record `nct05123482` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 1/2 trial of Puxitatug samrotecan, Rilvegostomig, Saruparib in ovarian cancer and endometrial cancer, run by AstraZeneca, now recruiting.

## Summary

A Phase I/IIa Study of AZD8205 Given Alone or Combined, in Participants With Advanced/Metastatic Solid Malignancies is a phase 1/2 interventional study registered as NCT05123482 by AstraZeneca, with 460 participants planned, started 2021-10-18 and due to reach its primary completion in 2027-09-29. Interventions recorded: AZD8205, AZD8205 and AZD2936 (Rilvegostomig), AZD8205 and AZD5305 (saruparib), AZD8205 and AZD5305 (saruparib) and AZD2936 (rilvegostomig), AZD8205 in combination with AZD9574. Conditions listed: Breast Cancer, Biliary Tract Carcinoma, Ovarian Cancer, Endometrial Cancer. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-16
- Tags: ctgov-ingest
- Registry id: NCT05123482
- Phase: 1/2
- Setting: A Phase I/IIa Multi-center, Open-label Master Protocol Dose Escalation and Expansion Study of AZD8205 as Monotherapy and in Combination With Anticancer Agents in Participants With Advanced Solid Tumors (BLUESTAR)
- Sponsor: AstraZeneca
- Enrolled: 460

## Sources

- ClinicalTrials.gov NCT05123482: https://clinicaltrials.gov/study/NCT05123482

## Connected records

- cancers: [Endometrial cancer](https://onco.cc/cancers/endometrial/), [Non-small-cell lung cancer](https://onco.cc/cancers/nsclc/), [Ovarian cancer](https://onco.cc/cancers/ovarian/), [Small-cell lung cancer](https://onco.cc/cancers/sclc/)
- drugs: [Palacaparib](https://onco.cc/drugs/palacaparib/), [Puxitatug samrotecan](https://onco.cc/drugs/puxitatug-samrotecan/), [Rilvegostomig](https://onco.cc/drugs/rilvegostomig/), [Saruparib](https://onco.cc/drugs/saruparib/)
- companies: [AstraZeneca](https://onco.cc/companies/astrazeneca/)

---
JSON: https://onco.cc/api/v1/entities/nct05123482.json