# Preoperative Chemoradiotherapy With CApecitabine and Temozolomide in MGMT Silenced, MSS, Locally Advanced RecTal Cancer

Source: https://onco.cc/trials/nct05136326/  
OnCo record `nct05136326` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of capecitabine and temozolomide in colorectal cancer, run by Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, now recruiting.

## Summary

Preoperative Chemoradiotherapy With CApecitabine and Temozolomide in MGMT Silenced, MSS, Locally Advanced RecTal Cancer is a phase 2, interventional study registered as NCT05136326 by Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, with a registry enrolment figure of 21 participants, started 2021-12-01 and due to reach its primary completion in 2023-12. Interventions recorded: External-beam radiation; Capecitabine; Temozolomide. Conditions listed: Rectal Cancer. Primary outcome: To evaluate the rate of complete pathologic response (pCR). Colorectal eligibility wording from the registry: "* Histologically confirmed diagnosis of rectal adenocarcinoma, with centrally confirmed mismatch repair proficiency (MSS) by PCR, lack of MGMT expression by IHC and MGMT promoter methylation by pyrosequencing;". Sites: Italy. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: CATARTIC
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05136326
- Phase: 2
- Setting: Multicenter Phase II Study of Preoperative Chemoradiotherapy With CApecitabine Plus Temozolomide in Patients With MGMT Silenced and Microsatellite Stable Locally Advanced RecTal Cancer: the CATARTIC Trial
- Sponsor: Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
- Enrolled: 21

## Sources

- ClinicalTrials.gov NCT05136326: https://clinicaltrials.gov/study/NCT05136326

## Connected records

- cancers: [Mismatch-repair deficient (MSI-high) colorectal cancer](https://onco.cc/cancers/msi-high-colorectal/), [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- drugs: [Capecitabine](https://onco.cc/drugs/capecitabine/), [Temozolomide](https://onco.cc/drugs/temozolomide/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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