# Adjuvant mFOLFIRINOX for High-risk Stage III Colon Cancer

Source: https://onco.cc/trials/nct05179889/  
OnCo record `nct05179889` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2/3 trial of fOLFIRINOX / mFOLFIRINOX and fOLFOX (5-FU, leucovorin, oxaliplatin) in colorectal cancer, run by Chungnam National University Hospital, now recruiting.

## Summary

Adjuvant mFOLFIRINOX for High-risk Stage III Colon Cancer is a phase 2/3, randomised interventional study registered as NCT05179889 by Chungnam National University Hospital, with a registry enrolment figure of 308 participants, started 2021-07-06 and due to reach its primary completion in 2028-07-05. Interventions recorded: mFOLFIRINOX; mFOLFOX 6. Conditions listed: Colon Cancer Stage III. Primary outcome: Disease free survival (DFS). Colorectal eligibility wording from the registry: "Pathologically confirmed high-risk stage III colon adenocarcinoma (pT4N1 or pTanyN2)". Sites: South Korea. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05179889
- Phase: 2/3
- Setting: mFOLFIRINOX Versus mFOLFOX 6 as Adjuvant Treatment for High Risk Stage III (pT4N1/2 or pTanyN2) Colon Cancer: Multicenter, Open Labeled, Randomized, Phase II Study
- Sponsor: Chungnam National University Hospital
- Enrolled: 308

## Sources

- ClinicalTrials.gov NCT05179889: https://clinicaltrials.gov/study/NCT05179889

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Platinum agents](https://onco.cc/technologies/platinum/), [Topoisomerase-I inhibitors (and ADC payloads)](https://onco.cc/technologies/topoisomerase-inhibitors/)
- drugs: [FOLFIRINOX / mFOLFIRINOX](https://onco.cc/drugs/folfirinox/), [FOLFOX (5-FU, leucovorin, oxaliplatin)](https://onco.cc/drugs/folfox/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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