# Cinrebafusp Alfa in Combination With Ramucirumab and Paclitaxel in HER2-High Gastric or GEJ Adenocarcinoma and in Combination With Tucatinib in HER2-Low Gastric or GEJ Andenocarinoma

Source: https://onco.cc/trials/nct05190445/  
OnCo record `nct05190445` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of Cinrebafusp alfa, Ramucirumab and Tucatinib in gastric & gastro-oesophageal junction cancer, run by Pieris Pharmaceuticals, Inc., active and no longer recruiting.

## Summary

Cinrebafusp Alfa in Combination With Ramucirumab and Paclitaxel in HER2-High Gastric or GEJ Adenocarcinoma and in Combination With Tucatinib in HER2-Low Gastric or GEJ Andenocarinoma is a phase 2 interventional study registered as NCT05190445 by Pieris Pharmaceuticals, Inc., with 80 participants enrolled, started 2021-11-01 and due to reach its primary completion in 2023-02-01. Interventions recorded: Cinrebafusp alfa (PRS-343) in combination with ramucirumab and paclitaxel and Cinrebafusp alfa (PRS-343) in combination with tucatinib.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-16
- Tags: pipeline; ctgov-ingest
- Registry id: NCT05190445
- Phase: 2
- Setting: A Phase 2, Multi-Center, Open-Label Study of Cinrebafusp Alfa (PRS-343) in Combination With Ramucirumab and Paclitaxel in Patients With HER2-Positive Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma and in Combination With Tucatinib in Patients With HER2 Low Gastric or Gastroesophageal Junction (GEJ) Adenocarcinoma
- Sponsor: Pieris Pharmaceuticals, Inc.
- Enrolled: 80

## Sources

- ClinicalTrials.gov NCT05190445: https://clinicaltrials.gov/study/NCT05190445

## Connected records

- cancers: [Gastric & gastro-oesophageal junction cancer](https://onco.cc/cancers/gastric/)
- drugs: [Cinrebafusp alfa](https://onco.cc/drugs/cinrebafusp-alfa/), [Ramucirumab](https://onco.cc/drugs/ramucirumab/), [Tucatinib](https://onco.cc/drugs/tucatinib/)

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