# Neoadjuvant FOLFOXIRI Versus Immediate Surgery for Stage II and III Colon Cancers

Source: https://onco.cc/trials/nct05194878/  
OnCo record `nct05194878` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial in colorectal cancer, run by Sun Yat-sen University, now recruiting.

## Summary

Neoadjuvant FOLFOXIRI Versus Immediate Surgery for Stage II and III Colon Cancers is a phase 3, randomised interventional study registered as NCT05194878 by Sun Yat-sen University, with a registry enrolment figure of 840 participants, started 2021-12-01 and due to reach its primary completion in 2024-12. Interventions recorded: neoadjuvant chemotherapyI; Colectomy; adjuvant chemotherapy. Conditions listed: Colon Cancer Stage II; Colon Cancer Stage III. Primary outcome: Disease-free survival. Colorectal eligibility wording from the registry: "* Histologically proven adenocarcinoma or high grade dysplasia on histology plus unequivocal radiological evidence of invasive cancer of the colon(≥ 12 cm from the anal verge)". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05194878
- Phase: 3
- Setting: Phase III Study of Neoadjuvant FOLFOXIRI Chemotherapy Versus Immediate Surgery for High-risk Resectable Stage II and III Colon Cancers
- Sponsor: Sun Yat-sen University
- Enrolled: 840

## Sources

- ClinicalTrials.gov NCT05194878: https://clinicaltrials.gov/study/NCT05194878

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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