# Neoadjuvant FOLFOXIRI Versus CapeOX Chemotherapy for Local Advanced Rectal Cancer

Source: https://onco.cc/trials/nct05201430/  
OnCo record `nct05201430` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 3 trial of FOLFOXIRI and cAPOX (capecitabine, oxaliplatin) in colorectal cancer, run by Fudan University, now recruiting.

## Summary

Neoadjuvant FOLFOXIRI Versus CapeOX Chemotherapy for Local Advanced Rectal Cancer is a phase 3, randomised interventional study registered as NCT05201430 by Fudan University, with a registry enrolment figure of 300 participants, started 2021-08-27 and due to reach its primary completion in 2024-06. Interventions recorded: FOLFOXIRI; CapeOX. Conditions listed: Rectal Cancer. Primary outcome: 3-year disease free survival. Colorectal eligibility wording from the registry: "* MRI evaluated of T3-4 or N+ rectal cancer;". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: RCNAC
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05201430
- Phase: 3
- Setting: Neoadjuvant FOLFOXIRI Chemotherapy Versus CapeOX Chemotherapy for Local Advanced Rectal Cancer: An Open Label Randomized Controlled Phase III Trial
- Sponsor: Fudan University
- Enrolled: 300

## Sources

- ClinicalTrials.gov NCT05201430: https://clinicaltrials.gov/study/NCT05201430

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [Platinum agents](https://onco.cc/technologies/platinum/), [Topoisomerase-I inhibitors (and ADC payloads)](https://onco.cc/technologies/topoisomerase-inhibitors/)
- drugs: [CAPOX (capecitabine, oxaliplatin)](https://onco.cc/drugs/capox/), [FOLFOXIRI (5-FU, leucovorin, oxaliplatin, irinotecan)](https://onco.cc/drugs/folfoxiri/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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