# Modified Sandwich Therapeutic Regimen for Locally Advanced Rectal Cancer

Source: https://onco.cc/trials/nct05228431/  
OnCo record `nct05228431` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of cAPOX (capecitabine, oxaliplatin) in colorectal cancer, run by Zhen-Hai Lu, now recruiting.

## Summary

Modified Sandwich Therapeutic Regimen for Locally Advanced Rectal Cancer is a phase 2, interventional study registered as NCT05228431 by Zhen-Hai Lu, with a registry enrolment figure of 121 participants, started 2022-03-02 and due to reach its primary completion in 2027-05-01. Interventions recorded: XELOX; Capecitabine monotherapy; Radiation. Conditions listed: Advanced Rectal Cancer. Primary outcome: Rate of pCR. Colorectal eligibility wording from the registry: "Pathological confirmed rectal adenocarcinoma". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05228431
- Phase: 2
- Setting: Single Arm and Phase II Clinical Trial of a Sandwich Regimen as XELOX Regimen and Capecitabine Alternate Administration Combined With Preoperative Intensity Modulated Radiation Therapy for pMMR Locally Advanced Rectal Cancer
- Sponsor: Zhen-Hai Lu
- Enrolled: 121

## Sources

- ClinicalTrials.gov NCT05228431: https://clinicaltrials.gov/study/NCT05228431

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [Cytotoxic chemotherapy](https://onco.cc/technologies/cytotoxic-chemotherapy/), [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/), [Platinum agents](https://onco.cc/technologies/platinum/)
- drugs: [CAPOX (capecitabine, oxaliplatin)](https://onco.cc/drugs/capox/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct05228431.json