# Single Arm Study of Neoadjuvant Dostarlimab in Stage II and III Deficient Mismatch Repair Colon Cancers

Source: https://onco.cc/trials/nct05239546/  
OnCo record `nct05239546` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of dostarlimab in colorectal cancer, run by University of Iowa, now recruiting.

## Summary

Single Arm Study of Neoadjuvant Dostarlimab in Stage II and III Deficient Mismatch Repair Colon Cancers is a phase 2, interventional study registered as NCT05239546 by University of Iowa, with a registry enrolment figure of 25 participants, started 2023-03-24 and due to reach its primary completion in 2028-06-30. Interventions recorded: Dostarlimab. Conditions listed: Colon Cancer; dMMR Colorectal Cancer. Primary outcome: Major Clinical Response (MCR) Rate. Colorectal eligibility wording from the registry: "* Biopsy proven dMMR (by IHC), Stage II or III colon cancer per CT imaging correlation with AJCC 8th edition, 2017, amendable to en block surgical resection as determined by colorectal surgeon". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Also known as: NAIO
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05239546
- Phase: 2
- Setting: Phase II, Single Arm Study of Neoadjuvant Dostarlimab (TSR-042) in Stage II and III Deficient Mismatch Repair Colon Cancers
- Sponsor: University of Iowa
- Enrolled: 25

## Sources

- ClinicalTrials.gov NCT05239546: https://clinicaltrials.gov/study/NCT05239546

## Connected records

- cancers: [Colon cancer (adenocarcinoma of the colon)](https://onco.cc/cancers/colon-cancer/), [Mismatch-repair deficient (MSI-high) colorectal cancer](https://onco.cc/cancers/msi-high-colorectal/)
- technologies: [Immune checkpoint inhibitors](https://onco.cc/technologies/checkpoint-inhibitor/)
- drugs: [Dostarlimab](https://onco.cc/drugs/dostarlimab/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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