# Neoadjuvant Long-course Chemoradiation Plus PD-1 Blockade for Mid-low Locally Advanced Rectal Cancer

Source: https://onco.cc/trials/nct05245474/  
OnCo record `nct05245474` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by Beijing Friendship Hospital, now recruiting.

## Summary

Neoadjuvant Long-course Chemoradiation Plus PD-1 Blockade for Mid-low Locally Advanced Rectal Cancer is a phase 2, randomised interventional study registered as NCT05245474 by Beijing Friendship Hospital, with a registry enrolment figure of 186 participants, started 2022-04-01 and due to reach its primary completion in 2024-03-01. Interventions recorded: Long-course chemoradiation, with or without Tislelizumab (PD-1 inhibitor). Conditions listed: Locally Advanced Rectal Cancer. Primary outcome: pCR rate. Colorectal eligibility wording from the registry: "* biopsy diagnosed rectal adenocarcinoma, distal margin within 10cm to anal verge". Sites: China. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05245474
- Phase: 2
- Setting: Efficacy and Safety of Neoadjuvant Long-course Chemoradiation Plus Tislelizumab in Mid-low Locally Advanced Rectal Cancer: a Phase II, Multi-center, Open-label, Randomized Controlled Trial (POLARSTAR Trial)
- Sponsor: Beijing Friendship Hospital
- Enrolled: 186

## Sources

- ClinicalTrials.gov NCT05245474: https://clinicaltrials.gov/study/NCT05245474

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- companies: [BeOne Medicines (formerly BeiGene)](https://onco.cc/companies/beone/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct05245474.json