# Trial of the Efficacy and Safety of Short and Long Course Radiation Therapy With/Without BMX-001

Source: https://onco.cc/trials/nct05254327/  
OnCo record `nct05254327` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial in colorectal cancer, run by University of Nebraska, now recruiting.

## Summary

Trial of the Efficacy and Safety of Short and Long Course Radiation Therapy With/Without BMX-001 is a phase 2, randomised interventional study registered as NCT05254327 by University of Nebraska, with a registry enrolment figure of 118 participants, started 2022-08-15 and due to reach its primary completion in 2027-05. Interventions recorded: BMX-001. Conditions listed: Rectal Cancer. Primary outcome: Efficacy of BMX-001 as measured by Grade 3 and above associated with gastrointestinal Toxicities; Efficacy of BMX-001 as measured by Grade 3 and above associated with genitourinary Toxicities; Efficacy of BMX-001 as measured by Grade 3 and above associated with skin Toxicities. Colorectal eligibility wording from the registry: "Patients with pathologically confirmed locally advanced rectal adenocarcinoma who will be receiving total neoadjuvant therapy regimen with curative intent". Sites: United States. No results are recorded here; the registry entry is the source.

## Fields

- Kind: Trial
- Status: recruiting
- Last checked: 2026-09-24
- Tags: ctgov-ingest; colorectal-deep-dive
- Registry id: NCT05254327
- Phase: 2
- Setting: A Randomized Phase 2 Trial of the Efficacy and Safety of Short and Long Course Radiation Therapy With and Without BMX-001 as Part of Total Neoadjuvant Therapy in Patients With Newly Diagnosed Locally Advanced Rectal Adenocarcinoma
- Sponsor: University of Nebraska
- Enrolled: 118

## Sources

- ClinicalTrials.gov NCT05254327: https://clinicaltrials.gov/study/NCT05254327

## Connected records

- cancers: [Rectal cancer](https://onco.cc/cancers/rectal-cancer/)
- technologies: [IMRT / IGRT (modern external beam)](https://onco.cc/technologies/imrt-igrt/)
- terms: [Colorectal cancer trials open today (registry snapshot)](https://onco.cc/terms/colorectal-trials-open-today/)

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JSON: https://onco.cc/api/v1/entities/nct05254327.json