# A Study of the Safety and Efficacy of Various Combinations of Avelumab as Therapy in Locally Advanced or Metastatic Urothelial Carcinoma (JAVELIN Bladder Medley)

Source: https://onco.cc/trials/nct05327530/  
OnCo record `nct05327530` (Trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)"; commercial use needs a licence.

## TL;DR

A phase 2 trial of Avelumab and Sacituzumab govitecan in bladder & urothelial cancer, run by EMD Serono Research & Development Institute, Inc., active and no longer recruiting.

## Summary

A Study of the Safety and Efficacy of Various Combinations of Avelumab as Therapy in Locally Advanced or Metastatic Urothelial Carcinoma (JAVELIN Bladder Medley) is a phase 2 interventional study registered as NCT05327530 by EMD Serono Research & Development Institute, Inc., with 256 participants enrolled, started 2022-08-17 and due to reach its primary completion in 2025-06-20. Interventions recorded: Avelumab, Sacituzumab Govitecan (SG), M6223, NKTR-255 and JB100. Results have been posted on the registry.

## Fields

- Kind: Trial
- Status: active
- Last checked: 2026-09-16
- Tags: pipeline; ctgov-ingest
- Registry id: NCT05327530
- Phase: 2
- Setting: A Phase II, Multicenter, Randomized, Open Label, Parallel-Arm, Umbrella Study of Avelumab (MSB0010718C) in Combination With Other AntiTumor Agents as a Maintenance Treatment in Participants With Locally Advanced or Metastatic Urothelial Carcinoma Whose Disease Did Not Progress With First Line Platinum-Containing Chemotherapy (JAVELIN Bladder Medley)
- Sponsor: EMD Serono Research & Development Institute, Inc.
- Enrolled: 256

## Sources

- ClinicalTrials.gov NCT05327530: https://clinicaltrials.gov/study/NCT05327530

## Connected records

- cancers: [Bladder & urothelial cancer](https://onco.cc/cancers/urothelial/)
- drugs: [Avelumab](https://onco.cc/drugs/avelumab/), [Sacituzumab govitecan](https://onco.cc/drugs/sacituzumab-govitecan/)
- companies: [Merck KGaA (EMD Serono)](https://onco.cc/companies/merck-kgaa/)

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